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tech@sbsbio.com
from China, for the World
for
S
uperior
B
iology
S
ervices since
2000
Home
Product
All Products
Custom Services
Catalog Products
Innovative Systems
Nucleic Acid Related
Natural Compounds
Synthetic Biology
Enzymes
POCT Solution
LAMP
RPA
CRISPR
DNA-Free Enzymes
Freeze-Drying System
Lateral Flow System
About
About SBS
Achievements
Ecosystem
Legal Statement
Contact
…
Home
Product
All Products
Custom Services
Catalog Products
Innovative Systems
Nucleic Acid Related
Natural Compounds
Synthetic Biology
Enzymes
POCT Solution
LAMP
RPA
CRISPR
DNA-Free Enzymes
Freeze-Drying System
Lateral Flow System
About
About SBS
Achievements
Ecosystem
Legal Statement
Contact
Login
All Categories - SBS Genetech - for Superior Biology Services since 2000
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Cell-Related
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Recombinant Human KRas4B (G13D, His-Tag)
Beyotime’s recombinant human KRas4B G13D (rhKRas4B G13D) was expressed in E.coli and purified, which mutate the code 12 glycine to cysteine of the mature form KRas4B (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>KRas gene located on the 12p11.1–12p12.1. The KRas is a member of the small GTPase superfamily, which encodes two highly related protein isoforms, KRas4B and KRas4A. KRas4B and KRas4A consist of 188 and 189 amino acids, respectively, due to different clipping of the fourth exon in mammalian cells. These proteins have different structures in their C-terminal region. KRas4B contains a polybasic stretch of eight lysines and KRas4A presents a palmitoylated cysteine and two polybasic regions. The localization and trafficking of KRas4B relies on the presence of polybasic residues that anchor the protein to the inner leaflet of the plasma membrane, whereas the membrane-targeting signals in KRas4A are two polybasic regions and an additional palmitoyl group, that independently contribute to the plasma membrane localization and signal output.<br>The term KRas is generally referred to as KRas4B due to the high level of mRNA encoding KRas4B in cells. KRas4B is by far the mo
$133.00 - $5,666.00
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Recombinant Human KRas4B (G12V, His-Tag)
Beyotime’s recombinant human KRas4B G12D (rhKRas4B G12D) was expressed in E.coli and purified, which mutate the code 12 glycine to cysteine of the mature form KRas4B (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>KRas gene located on the 12p11.1–12p12.1. The KRas is a member of the small GTPase superfamily, which encodes two highly related protein isoforms, KRas4B and KRas4A. KRas4B and KRas4A consist of 188 and 189 amino acids, respectively, due to different clipping of the fourth exon in mammalian cells. These proteins have different structures in their C-terminal region. KRas4B contains a polybasic stretch of eight lysines and KRas4A presents a palmitoylated cysteine and two polybasic regions. The localization and trafficking of KRas4B relies on the presence of polybasic residues that anchor the protein to the inner leaflet of the plasma membrane, whereas the membrane-targeting signals in KRas4A are two polybasic regions and an additional palmitoyl group, that independently contribute to the plasma membrane localization and signal output.<br>The term KRas is generally referred to as KRas4B due to the high level of mRNA encoding KRas4B in cells. KRas4B is by far the mo
$133.00 - $5,666.00
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Recombinant Human KRas4B (G12D, His-Tag)
Beyotime’s recombinant human KRas4B G12D (rhKRas4B G12D) was expressed in E.coli and purified, which mutate the code 12 glycine to cysteine of the mature form KRas4B (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>KRas gene located on the 12p11.1–12p12.1. The KRas is a member of the small GTPase superfamily, which encodes two highly related protein isoforms, KRas4B and KRas4A. KRas4B and KRas4A consist of 188 and 189 amino acids, respectively, due to different clipping of the fourth exon in mammalian cells. These proteins have different structures in their C-terminal region. KRas4B contains a polybasic stretch of eight lysines and KRas4A presents a palmitoylated cysteine and two polybasic regions. The localization and trafficking of KRas4B relies on the presence of polybasic residues that anchor the protein to the inner leaflet of the plasma membrane, whereas the membrane-targeting signals in KRas4A are two polybasic regions and an additional palmitoyl group, that independently contribute to the plasma membrane localization and signal output.<br>The term KRas is generally referred to as KRas4B due to the high level of mRNA encoding KRas4B in cells. KRas4B is by far the mo
$133.00 - $5,666.00
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Recombinant Human KRas4B (G12C, His-Tag)
Beyotime’s recombinant human KRas4B (rhKRas4B) was expressed in E.coli and purified, which contain the mature form KRas4B (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>Ras (KRas, HRas and NRas) is the most frequently mutated gene family in cancers，they differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Ras directly interacts with and activates several downstream effector pathways including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Mutations in Ras gene disrupt the guanine exchange cycle, typically by becoming GAP-independent and ‘locking’ Ras in the active, GTP-bound state, thereby activating downstream signaling pathways resulting in tumor cell growth.<br>KRas was first identified as a viral oncogene in the Kirsten Rat Sarcoma virus and KRas protein was first found as a p21 GTPase. The protein relays signals from outside the cell to the cell’s nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on sp
$133.00 - $5,666.00
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Recombinant Human KRas4B (His-Tag)
Beyotime’s recombinant human KRas4B (rhKRas4B) was expressed in E.coli and purified, which contain the mature form KRas4B (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>Ras (KRas, HRas and NRas) is the most frequently mutated gene family in cancers，they differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Ras directly interacts with and activates several downstream effector pathways including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Mutations in Ras gene disrupt the guanine exchange cycle, typically by becoming GAP-independent and ‘locking’ Ras in the active, GTP-bound state, thereby activating downstream signaling pathways resulting in tumor cell growth.<br>KRas was first identified as a viral oncogene in the Kirsten Rat Sarcoma virus and KRas protein was first found as a p21 GTPase. The protein relays signals from outside the cell to the cell’s nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on sp
$133.00 - $5,666.00
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Recombinant Human KRas4A (His-Tag)
Beyotime’s recombinant human KRas4A (rhKRas4A) was expressed in E.coli and purified, which contain the mature form KRas4A (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>Ras (KRas, HRas and NRas) is the most frequently mutated gene family in cancers，they differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Ras directly interacts with and activates several downstream effector pathways including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Mutations in Ras gene disrupt the guanine exchange cycle, typically by becoming GAP-independent and ‘locking’ Ras in the active, GTP-bound state, thereby activating downstream signaling pathways resulting in tumor cell growth.<br>KRas was first identified as a viral oncogene in the Kirsten Rat Sarcoma virus and KRas protein was first found as a p21 GTPase. The protein relays signals from outside the cell to the cell’s nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on sp
$133.00 - $5,666.00
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Recombinant Human HRas (His-Tag)
Beyotime’s recombinant human HRas (rhHRas) was expressed in E.coli and purified, which contain the mature form HRas (2-186aa) fusion with 6X His tag (HHHHHH) at the N-terminus.<br>Ras (HRas, NRas and KRas) is the most frequently mutated gene family in cancers，they differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Ras directly interacts with and activates several downstream effector pathways including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Mutations in Ras gene disrupt the guanine exchange cycle, typically by becoming GAP-independent and ‘locking’ Ras in the active, GTP-bound state, thereby activating downstream signaling pathways resulting in tumor cell growth.<br>HRas, from "Harvey Rat sarcoma virus", is an enzyme that in humans is encoded by the HRas gene. The HRas gene is located on the short (p) arm of chromosome 11 at position 15.5. HRas activate the RAS–RAF–MEK–ERK pathway. Typical hotspots for HRas mutations are found at codon 12, 13 and 61, resulting
$133.00 - $5,666.00
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Recombinant Human NRas (Flag-Tag)
Beyotime’s recombinant human NRas (rhNRas) was expressed in E.coli and purified, which contain the mature form NRas (2-186aa) with Flag tag (DYKDDDDK) at the N-terminus.<br>Ras (NRas, HRas and KRas) is the most frequently mutated gene family in cancers，they differ significantly only in the C-terminal 40 amino acids. These Ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Ras directly interacts with and activates several downstream effector pathways including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways. Mutations in Ras gene disrupt the guanine exchange cycle, typically by becoming GAP-independent and ‘locking’ Ras in the active, GTP-bound state, thereby activating downstream signaling pathways resulting in tumor cell growth.<br>NRas oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. Mutations which change amino acid residues 12, 13 or 61 activate the potential of NRas to trans
$133.00 - $5,666.00
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2019-nCoV Spike Protein RBD (Delta, L452R, T478K, 319-541)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ∼180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Convertin434g Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-Co
$1,036.00 - $2,762.00
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2019-nCoV Spike Protein RBD (Delta, L452R, T478K, 319-535)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ∼180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Converting Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-CoV-2
$1,036.00 - $2,762.00
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2019-nCoV Spike Protein RBD (K417N, E484K, N501Y)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ~180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Converting Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-CoV-2
$1,036.00 - $2,762.00
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2019-nCoV Spike Protein RBD (N501Y)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ~180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Converting Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-CoV-2
$1,036.00 - $2,762.00
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2019-nCoV Spike Protein RBD (E484K)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ~180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Converting Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-CoV-2
$1,036.00 - $2,762.00
Buy now
2019-nCoV Spike Protein RBD
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. Spike Protein, the main surface antigen of the coronavirus, is a ∼180kD glycoprotein that crucial for viral fusion and entry into the host cells. It is a homotrimeric, consisting of two subunits, S1 and S2. In SARS-CoV-2, proteolytic cleavage of spike protein into S1 and S2 subunits is required for its activation. The first step of coronavirus infection of virus is the interaction of the spike protein to certain receptors on host cells. The S1 subunit is focused on attachment of the protein to the receptor while the S2 subunit is involved with membrane fusion. The receptor binding domain (RBD) locates in the C-terminal region of S1, and it binds to Angiotensin-Converting Enzyme 2 (ACE2) of host cells with high affinity and fast binding kinetic. Blocking the interaction between ACE2 and RBD inhibits the viral infection. RBD-specific antibodies have been shown to inhibit the attachment of RBD to ACE2-expressing cells, suggesting RBD as a potential target for vaccinations or therapy of SARS-CoV-2
$1,036.00 - $2,762.00
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2019-nCoV Nucleocapsid Protein
Beyotime’s recombinant human RhoA (rhRhoA) was expressed in E. coli and purified, which contain the mature form RhoA (1-190aa) with 3X Flag tag at the C-terminus.<br>RhoA is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. RhoA regulates the dynamic organization of the actin cytoskeleton (polymerization, actomyosin contractility or stress fiber formation) and cellular functions dependent on the dynamic actin cytoskeleton, including cell morphology, polarity, cell adhesion, cell migration/motility, cell protrusion, extracellular action, endocytosis, cell cycle regulation, cytoplasmic division, cell development and its processes such as transcriptional control and cell proliferation. RhoA is also involved in the regulation of microtubule dynamics [1-2].
$120.00 - $2,533.00
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Recombinant Human RhoA (Flag-Tag)
Beyotime’s recombinant human RhoA (rhRhoA) was expressed in E. coli and purified, which contain the mature form RhoA (1-190aa) with 3X Flag tag at the C-terminus.<br>RhoA is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. RhoA regulates the dynamic organization of the actin cytoskeleton (polymerization, actomyosin contractility or stress fiber formation) and cellular functions dependent on the dynamic actin cytoskeleton, including cell morphology, polarity, cell adhesion, cell migration/motility, cell protrusion, extracellular action, endocytosis, cell cycle regulation, cytoplasmic division, cell development and its processes such as transcriptional control and cell proliferation. RhoA is also involved in the regulation of microtubule dynamics [1-2].
$120.00 - $2,533.00
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Recombinant Rat Prolactin
Prolactin, also named PRL and lactotrope is a peptide hormone, encoded by the PRL gene. The structure of prolactin is similar to that of growth hormone and placental lactogen. There are mainly three different forms of prolactin in regard to size: little prolactin, big prolactin and big big prolactin. Little prolactin is the predominant form. Although often associated with human milk production, prolactin plays a wide range of other roles in both humans and other verterbrates. Recombinant murine prolactin is a 22.4kDa globular protein containing 197 amino acid residues and shares 77%~90%a.a. sequence identity with human and rat prolactin.
$223.00 - $1,806.00
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Recombinant Murine Prolactin
Prolactin, also named PRL and lactotrope is a peptide hormone, encoded by the PRL gene. The structure of prolactin is similar to that of growth hormone and placental lactogen. There are mainly three different forms of prolactin in regard to size: little prolactin, big prolactin and big big prolactin. Little prolactin is the predominant form. Although often associated with human milk production, prolactin plays a wide range of other roles in both humans and other verterbrates. Recombinant murine prolactin is a 22.4kDa globular protein containing 197 amino acid residues and shares 77%~90%a.a. sequence identity with human and rat prolactin.
$223.00 - $1,806.00
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Recombinant Human PTH7-84, 15N
Parathyroid hormone (PTH) is a single polypeptide of 78 amino acids. It is a critical hormone in the regulation of Ca2+ homeostasis and secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low.
$223.00 - $1,806.00
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Recombinant Human PCT/Procalcitonin
Procalcitonin (PCT) belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.). PCT is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. PCT is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. But its level is related to the severity of bacterial sepsis, it is considered to be one of the earliest and most specific markers of sepsis.
$606.00 - $3,590.00
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